Literature associating LGALS8 and cholesteatoma of middle ear
LGALS8 [ENSP00000435460]
Galectin-8; Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture . Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium . Also required to restrict infection of Picornaviridae viruses . Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans .
Synonyms: LGALS8, LGALS8p, hLGALS8, B1ANM0, E9PJ77 ...