DISEASES

Disease-gene associations mined from literature

Literature associating GPR68 and amelogenesis imperfecta

GPR68 [ENSP00000434045]

Ovarian cancer G-protein coupled receptor 1; Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity); Belongs to the G-protein coupled receptor 1 family.

Synonyms:  GPR68,  GPR68p,  hGPR68,  A0A024R6D5,  A1A5B2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM