DISEASES

Disease-gene associations mined from literature

Literature associating ST5 and meningococcal meningitis

ST5 [ENSP00000433528]

Suppression of tumorigenicity 5 protein; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth; DENN/MADD domain containing

Synonyms:  ST5,  ST5p,  hST5,  B4DDL8,  E9PI58 ...

Linkouts:  STRING  Pharos  UniProt