DISEASES

Disease-gene associations mined from literature

Literature associating API5 and hereditary desmoid disease

API5 [ENSP00000431391]

Fibroblast growth factor 2-interacting factor; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs; Armadillo-like helical domain containing

Synonyms:  API5,  API5p,  hAPI5,  B4E283,  E9PQK6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM