DISEASES

Disease-gene associations mined from literature

Literature associating EPHX2 and anosognosia

EPHX2 [ENSP00000430269]

Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy- octadec-9E-enoic acid; HAD Asp-based non-protein phosphatases

Synonyms:  EPHX2,  EPHX2p,  hEPHX2,  E5RFH6,  E5RFU2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM