DISEASES

Disease-gene associations mined from literature

Literature associating EBF2 and localized osteosarcoma

EBF2 [ENSP00000430241]

Transcription factor COE2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).

Synonyms:  EBF2,  EBF2p,  hEBF2,  B2RNT0,  B7Z934 ...

Linkouts:  STRING  Pharos  UniProt  OMIM