DISEASES

Disease-gene associations mined from literature

Literature associating MYBL1 and tonsil cancer

MYBL1 [ENSP00000429633]

V-myb avian myeloblastosis viral oncogene homolog-like 1; Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity); Myb/SANT domain containing

Synonyms:  MYBL1,  MYBL1p,  hMYBL1,  A-MYB,  E7EWZ1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM