DISEASES

Disease-gene associations mined from literature

Literature associating CCNC and uterine benign neoplasm

CCNC [ENSP00000428982]

SRB11 homolog; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Synonyms:  CCNC,  E5RFK5,  E5RFX8,  E5RHL8,  E5RI39 ...

Linkouts:  STRING  Pharos  UniProt  OMIM