DISEASES

Disease-gene associations mined from literature

Literature associating TCEA1 and Cockayne syndrome

TCEA1 [ENSP00000428426]

Transcription elongation factor S-II protein 1; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus; General transcription factors

Synonyms:  TCEA1,  TCEA1p,  hTCEA1,  B7Z4S1,  E5RFI1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM