DISEASES

Disease-gene associations mined from literature

Literature associating SMAD1 and small intestine neuroendocrine neoplasm

SMAD1 [ENSP00000426568]

Transforming growth factor-beta-signaling protein 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression; Belongs to the dwarfin/SMAD family.

Synonyms:  SMAD1,  SMAD1p,  hSMAD1,  D6RAY1,  D6RBH9 ...

Linkouts:  STRING  Pharos  UniProt