Disease-gene associations mined from literature

Literature associating FNIP1 and interdigitating dendritic cell sarcoma

FNIP1 [ENSP00000421985]

Folliculin interacting protein 1; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1; Belongs to the FNIP family.

Synonyms:  FNIP1,  FNIP1p,  hFNIP1,  B3KX44,  J3KNG8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM