Literature associating MFN1 and skin amelanotic melanoma
Transmembrane GTPase MFN1; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity.
Synonyms: MFN1, MFN1p, hMFN1, C9JQT7, C9JXQ1 ...