DISEASES

Disease-gene associations mined from literature

Literature associating DP2 and adenocarcinoma

DP2 [ENSP00000420616]

Transcription factor Dp-2 (E2F dimerization partner 2); Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.

Synonyms:  TFDP2,  TFDP2p,  hTFDP2,  C9J461,  C9J5D5 ...

Linkouts:  STRING  Pharos  UniProt #1 #2  OMIM