DISEASES

Disease-gene associations mined from literature

Literature associating BAG1 and coccidiosis

BAG1 [ENSP00000420514]

BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli; BCL2 associated athanogene family

Synonyms:  BAG1,  BAG1p,  hBAG1,  BAG1-001,  BAG1-003 ...

Linkouts:  STRING  Pharos  UniProt  OMIM