Disease-gene associations mined from literature

Literature associating FLNB and frontometaphyseal dysplasia

FLNB [ENSP00000420213]

Truncated actin-binding protein; Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro; Belongs to the filamin family.

Synonyms:  FLNB,  E7EN95,  O75369,  Q8WXT3,  ABP-278 ...

Linkouts:  STRING  Pharos  UniProt  OMIM