DISEASES

Disease-gene associations mined from literature

Literature associating GCSAM and diffuse large B-cell lymphoma

GCSAM [ENSP00000419485]

Germinal center-associated signaling and motility protein; Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.

Synonyms:  GCSAM,  C9IY73,  C9JY41,  F2Z3F7,  Q8N6F7 ...

Linkouts:  STRING  Pharos  UniProt