Disease-gene associations mined from literature

Literature associating SMYD3 and renal Wilms' tumor

SMYD3 [ENSP00000419184]

Zinc finger MYND domain-containing protein 1; Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'- CCCTCC-3' or 5'-GAGGGG-3' sequences; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.

Synonyms:  SMYD3,  SMYD3p,  hSMYD3,  A8MXR1,  B0QZ88 ...

Linkouts:  STRING  Pharos  UniProt