DISEASES

Disease-gene associations mined from literature

Literature associating MME and systolic heart failure

MME [ENSP00000418525]

Common acute lymphocytic leukemia antigen; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers; Belongs to the peptidase M13 family.

Synonyms:  MME,  C9IYX7,  C9J9X7,  C9JDZ3,  C9JR96 ...

Linkouts:  STRING  Pharos  UniProt