DISEASES

Disease-gene associations mined from literature

Literature associating PAEP and submucous uterine fibroid

PAEP [ENSP00000417898]

Pregnancy-associated endometrial alpha-2 globulin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa- zona pellucida binding and significantly suppresses progesterone- induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa; Lipocalins

Synonyms:  PAEP,  A0A024R8D8,  A6XNE0,  F2Z349,  P09466 ...

Linkouts:  STRING  Pharos  UniProt