Disease-gene associations mined from literature

Literature associating NCK1 and Wiskott-Aldrich syndrome

NCK1 [ENSP00000417273]

SH2/SH3 adaptor protein NCK-alpha; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors; SH2 domain containing

Synonyms:  NCK1,  NCK1p,  hNCK1,  C9J0K5,  C9J869 ...

Linkouts:  STRING  Pharos  UniProt