DISEASES

Disease-gene associations mined from literature

Literature associating CFB and choroiditis

CFB [ENSP00000416561]

Glycine-rich beta glycoprotein; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family.

Synonyms:  CFB,  F8WBL9,  BF,  F8WBL9p,  hF8WBL9 ...

Linkouts:  STRING  Pharos