Disease-gene associations mined from literature

Literature associating SERPINA1 and factor VIII deficiency

SERPINA1 [ENSP00000416066]

Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family.

Synonyms:  SERPINA1,  A0A0B4J278,  E9KL23,  G3V2B9,  G3V387 ...

Linkouts:  STRING  Pharos  UniProt