Disease-gene associations mined from literature

Literature associating C4B and louse-borne relapsing fever

C4B [ENSP00000415941]

Complement C4-B alpha chain; Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.

Synonyms:  C4B,  C4Bp,  hC4B,  A0A3B3ISA6,  A0A3B3ISD7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM