Literature associating PPP2R5C and ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Synonyms: PPP2R5C, PPP2R5Cp, hPPP2R5C, G3V292, G3V2U3 ...