DISEASES

Disease-gene associations mined from literature

Literature associating TRIM32 and autosomal recessive limb-girdle muscular dystrophy type 2I

TRIM32 [ENSP00000408292]

RING-type E3 ubiquitin transferase TRIM32; Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo; Belongs to the TRIM/RBCC family.

Synonyms:  TRIM32,  TRIM32p,  hTRIM32,  A0A024R843,  Q13049 ...

Linkouts:  STRING  Pharos  UniProt