DISEASES

Disease-gene associations mined from literature

Literature associating TAF1 and X-linked dystonia-parkinsonism

TAF1 [ENSP00000406549]

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2- mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4; Belongs to the TAF1 family.

Synonyms:  TAF1,  TAF1p,  hTAF1,  P21675,  BA2R ...

Linkouts:  STRING  Pharos  UniProt