Literature associating ZBTB7B and benign recurrent intrahepatic cholestasis
Zinc finger and BTB domain-containing protein 15; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity); BTB domain containing
Synonyms: ZBTB7B, ZBTB7Bp, hZBTB7B, O15156, O15156p ...