Literature associating TBL1XR1 and acute promyelocytic leukemia
Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation; Belongs to the WD repeat EBI family.
Synonyms: TBL1XR1, TBL1XR1p, hTBL1XR1, C9IYU9, C9J3H2 ...