DISEASES

Disease-gene associations mined from literature

Literature associating BRAP and astereognosia

BRAP [ENSP00000403524]

RING-type E3 ubiquitin transferase BRAP2; Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport; Ring finger proteins

Synonyms:  BRAP,  BRAP-001,  BRAP-002,  BRAP-003,  J3KNN7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM