DISEASES

Disease-gene associations mined from literature

Literature associating SIGIRR and central nervous system tuberculosis

SIGIRR [ENSP00000403104]

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Synonyms:  SIGIRR,  C9JFX4,  E9PK23,  E9PLG6,  E9PSD9 ...

Linkouts:  STRING  Pharos  UniProt