Literature associating RUNX1T1 and hematologic cancer
Runt-related transcription factor 1; translocated to, 1 (cyclin D-related); Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal; Zinc fingers MYND-type
Synonyms: RUNX1T1, RUNX1T1p, hRUNX1T1, CBFA2T1, E5RFQ3 ...