DISEASES

Disease-gene associations mined from literature

Literature associating RUNX1T1 and hematologic cancer

RUNX1T1 [ENSP00000402257]

Runt-related transcription factor 1; translocated to, 1 (cyclin D-related); Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal; Zinc fingers MYND-type

Synonyms:  RUNX1T1,  RUNX1T1p,  hRUNX1T1,  CBFA2T1,  E5RFQ3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM