Literature associating ERN1 and arrhythmogenic right ventricular dysplasia 5
ERN1 [ENSP00000401445]
Serine/threonine-protein kinase/endoribonuclease IRE1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Synonyms: ERN1p, hERN1, O75460, O75460p, hO75460 ...