Disease-gene associations mined from literature

Literature associating MYD88 and monoclonal gammopathy of uncertain significance

MYD88 [ENSP00000401399]

Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine; TIR domain containing

Synonyms:  MYD88,  MYD88p,  hMYD88,  B4E3D6,  H0Y4G9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM