Disease-gene associations mined from literature

Literature associating HMGA1 and hypomyelinating leukodystrophy

HMGA1 [ENSP00000399888]

High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions; Canonical high mobility group

Synonyms:  HMGA1,  HMGA1p,  hHMGA1,  P17096,  Q5T6U8 ...

Linkouts:  STRING  Pharos  UniProt