DISEASES

Disease-gene associations mined from literature

Literature associating CYR61 and uveal melanoma

CYR61 [ENSP00000398736]

Insulin-like growth factor-binding protein 10; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3; Belongs to the CCN family.

Synonyms:  CYR61,  CYR61p,  hCYR61,  O00622,  Q6FI18 ...

Linkouts:  STRING  Pharos  UniProt  OMIM