Disease-gene associations mined from literature

Literature associating PRF1 and nasal cavity lymphoma

PRF1 [ENSP00000398568]

Perforin 1 (pore forming protein); Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes; Belongs to the complement C6/C7/C8/C9 family.

Synonyms:  PRF1,  PRF1p,  hPRF1,  P14222,  S5RDP5 ...

Linkouts:  STRING  Pharos  UniProt