DISEASES

Disease-gene associations mined from literature

Literature associating IL34 and tenosynovial giant cell tumor

IL34 [ENSP00000397863]

Interleukin 34; Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1; Belongs to the IL-34 family.

Synonyms:  IL34,  IL34p,  hIL34,  A0A024QZ87,  H3BPB7 ...

Linkouts:  STRING  Pharos  UniProt