Literature associating DHFR and pediatric osteosarcoma
Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
Synonyms: DHFR, A0A024RAQ3, B0YJ76, B4DDD2, B4DM58 ...