DISEASES

Disease-gene associations mined from literature

Literature associating SESN1 and endometrial adenosquamous carcinoma

SESN1 [ENSP00000393762]

P53-regulated protein PA26; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity); Belongs to the sestrin family.

Synonyms:  SESN1,  SESN1p,  hSESN1,  Q9Y6P5,  SESN1-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM