Literature associating GPSM1 and peroxisome biogenesis disorder 2A
Activator of G-protein signaling 3; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction; Belongs to the GPSM family.
Synonyms: GPSM1, GPSM1p, hGPSM1, Q86YR5, AGS3 ...