DISEASES

Disease-gene associations mined from literature

Literature associating LDB1 and hypotrichosis 2

LDB1 [ENSP00000392466]

Carboxyl-terminal LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).

Synonyms:  LDB1,  LDB1p,  hLDB1,  Q86U70,  CLIM2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM