DISEASES

Disease-gene associations mined from literature

Literature associating C1orf106 and colitis

C1orf106 [ENSP00000392105]

Chromosome 1 open reading frame 106; Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF- kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion.

Synonyms:  C1orf106,  C1ORF106,  C9JAT8,  E9PK29,  Q3KP66 ...

Linkouts:  STRING  Pharos  UniProt