Disease-gene associations mined from literature

Literature associating MEIOB and Y-linked spermatogenic failure 2

MEIOB [ENSP00000390778]

Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity); Belongs to the MEIOB family.

Synonyms:  MEIOB,  LINC00254,  H3BSU6,  H3BU10,  H3BU18 ...

Linkouts:  STRING  Pharos  UniProt