DISEASES

Disease-gene associations mined from literature

Literature associating CTU1 and myxopapillary ependymoma

CTU1 [ENSP00000390011]

ATP-binding domain-containing protein 3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

Synonyms:  CTU1,  CTU1p,  hCTU1,  Q7Z7A3,  ATPBD3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM