DISEASES

Disease-gene associations mined from literature

Literature associating ADIPOQ and hyperglycemia

ADIPOQ [ENSP00000389814]

Adipocyte, C1q and collagen domain-containing protein; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Synonyms:  ADIPOQ,  A8K660,  Q15848,  A8K660p,  hA8K660 ...

Linkouts:  STRING  Pharos  UniProt