Disease-gene associations mined from literature

Literature associating RARG and embryonal cancer

RARG [ENSP00000388510]

Nuclear receptor subfamily 1 group B member 3; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity); Belongs to the nuclear hormone receptor family. NR1 subfamily.

Synonyms:  RARG,  A8K3H3,  F1D8P1,  H3BMK1,  H3BMY6 ...

Linkouts:  STRING  Pharos  UniProt