Literature associating SOS1 and Costello syndrome
Son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity); Pleckstrin homology domain containing
Synonyms: SOS1, SOS1p, hSOS1, C9K0N6, G5E9C8 ...