Literature associating ARTN and Hirschsprung's disease
Neublastin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue; GDNF family ligands
Synonyms: ARTN, E9PIK2, E9PLG3, E9PN22, Q5T4W7 ...