DISEASES

Disease-gene associations mined from literature

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Literature associating ACAN and achondrogenesis

ACAN [ENSP00000387356]

Chondroitin sulfate proteoglycan core protein 1; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region; C-type lectin domain containing

Synonyms:  ACAN,  E7ENV9,  E7EX88,  H0YM81,  Q6LE94 ...

Linkouts:  STRING  Pharos  OMIM

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.