Literature associating NLRX1 and branchiootorenal syndrome 2
Nucleotide-binding oligomerization domain protein 26; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species; NLR family
Synonyms: NLRX1, NLRX1p, hNLRX1, B7Z889, C9J0R6 ...